![]() ![]() When vitamin K is given IV, it should be administered by slow infusion to minimize risk of anaphylaxis.Īnswer B is incorrect because the reversal agent for dabigatran is idarucizumab (Praxbind). ![]() Idarucizumab is a monoclonal antibody fragment that specifically binds dabigatran and its metabolites. It works by binding the factor Xa inhibitors and also increases tissue factor-initiated thrombin generation.Īndexanet alfa is the agent FDA-approved for life-threatening bleeding associated with apixaban (Eliquis) and rivaroxaban (Xarelto), both of which are factor Xa inhibitors. While edoxaban (Savaysa) is also a factor Xa inhibitor, andexanet alfa is not FDA-approved to reverse its activity.Īnswer C is correct. Flumazenil is the reversal agent for benzodiazepines. It competitively inhibits the activity at the benzodiazepine receptor site on the GABA/benzodiazepine receptor complex. It is important to keep in mind that using flumazenil for benzodiazepine reversal has an increased risk of seizures and therefore should be only given when absolutely necessary.Īnswer D is correct. Naloxone is an opioid antagonist used in overdoses. It is an opioid antagonist that displaces opioids at opioid receptor sites. ![]()
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