the author or copyright owner irrevocably grants to all users, for an unlimited period, the right to use, copy, or distribute the article, on condition that proper attribution is given.its content is universally and freely accessible, at no cost to the reader, via the Internet or otherwise.OA can also apply to non-scholarly content, like music, movies, and novels.Ī publication is considered in Open access if: While most of these are related to text only, a growing number are integrating text with images, data, and executable code. Any kind of digital content can be OA, from texts and data to software, audio, video, and multi-media. Open access (OA) means free access to information and unrestricted use of electronic resources for everyone. The Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities “By 'op en access' to the literature, we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the inte rnet itself."
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When vitamin K is given IV, it should be administered by slow infusion to minimize risk of anaphylaxis.Īnswer B is incorrect because the reversal agent for dabigatran is idarucizumab (Praxbind). Idarucizumab is a monoclonal antibody fragment that specifically binds dabigatran and its metabolites. It works by binding the factor Xa inhibitors and also increases tissue factor-initiated thrombin generation.Īndexanet alfa is the agent FDA-approved for life-threatening bleeding associated with apixaban (Eliquis) and rivaroxaban (Xarelto), both of which are factor Xa inhibitors. While edoxaban (Savaysa) is also a factor Xa inhibitor, andexanet alfa is not FDA-approved to reverse its activity.Īnswer C is correct. Flumazenil is the reversal agent for benzodiazepines. It competitively inhibits the activity at the benzodiazepine receptor site on the GABA/benzodiazepine receptor complex. 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